Asthmatic Medicine

Product Details:

Prolonged Release Metformin Tablets 500 mg represent an advanced formulation of a cornerstone medication in the management of type 2 diabetes mellitus. Designed for extended action, each tablet contains 1000 milligrams of metformin hydrochloride, a biguanide oral antihyperglycemic agent. This prolonged-release (PR) or extended-release (ER) formulation is engineered to release metformin gradually over an extended period, ensuring more stable blood glucose levels throughout the day and night while potentially improving gastrointestinal tolerability compared to immediate-release formulations. It is primarily indicated for adults with type 2 diabetes, especially those who are overweight or obese, where diet and exercise alone have not achieved adequate glycemic control. Metformin works through multiple mechanisms, including reducing hepatic glucose production, decreasing intestinal absorption of glucose, and improving insulin sensitivity by enhancing peripheral glucose uptake and utilization. This multifaceted action helps to lower both basal and postprandial plasma glucose levels without stimulating insulin secretion, thereby minimizing the risk of hypoglycemia when used as monotherapy.

The sustained-release profile of Metformin PR 1000 mg allows for convenient once-daily dosing, typically taken with the evening meal to optimize its therapeutic effects overnight. This regimen can significantly enhance patient adherence and reduce the fluctuation of metformin levels in the bloodstream. For adults, the usual starting dose of prolonged-release metformin is often 500 mg once daily, which may be gradually titrated up to 1000 mg, or even higher doses (up to a maximum of 2000 mg once daily), based on individual glycemic response and tolerability, as directed by a healthcare professional. Tablets should be swallowed whole and not crushed, chewed, or broken, as this would compromise the prolonged-release mechanism.